The first steps to establish a Canadian Reformed institution for the training of teachers were taken in 1976 at a meeting of the League of Canadian Reformed School Societies. Two years later, the Canadian Reformed Teachers College Association was formed with representatives from Ontario, Manitoba, Alberta, and British Columbia school societies serving as a Board of Governors. The CCRTC opened in September of 1981, with two full-time lecturers, two part-time instructors, and six students.

During the first years, classes were held in the Cornerstone Canadian Reformed church building in Hamilton. CCRTC operated from its own premises on Mohawk Road from 1988 to 1998 when it moved into its present facilities. Enrolment has been relatively stable and over the years CCRTC has graduated over 280 students, many of whom are currently employed by Canadian Reformed schools across Canada.